Danuta Szczesna-Cordary, PhD Email: email@example.com Myosin Light Chain Mutant Induced Cardiomyopathies The major theme of my research regards myosin and troponin-mediated cellular events that result in sarcomere shortening and muscle contraction studied at the molecular, myofilament and organ levels. Our recent research interests concentrate on the molecular and genetic causes of cardiomyopathy with a special […]
Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and will additionally look […]
The Szczesna- Cordary lab welcomes Ulises, undergraduate student at the University of Miami studying biochemistry and Italian! During his time in the lab, he will first be shadowing graduate students, assistant and research scientists to get more familiar with the equipment and projects in the lab and will eventually have a project on his own! […]
Jacob Rowe, first year graduate PIBS student gave his rotation symposium talk today! His project focused on two different mutations in the Essential Light Chain of myosin (A57G and D43) and how each modulate the Super Relaxed State (SRX) of myosin. Thank you for all the help and we hope you enjoyed your time in […]
Dr. Yuan, Our Recent Graduate, Continues Her Excellence as a Post-Doctoral Fellow at Univ. of Washington
We are proud to announce that Dr. Chen-Ching (Vicky) Yuan is pursuing her Post-Doctoral Fellowship at the University of Washington at Seattle in the laboratory of Dr. Michael Regnier. His laboratory studies the molecular mechanisms of cardiac and skeletal muscle disease and uses this information to develop novel gene therapies and proteins, cells and tissue engineering […]
The DSC family is excited to welcome Yoel Sitbon as its latest addition to our MCP graduate students. Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will […]
Congratulations to Sunil Yadav ( Danuta Szczesna-Cordary Lab) for receiving a two-year American Heart Association (AHA) AWRP Winter 2017 Predoctoral Fellowship for the work titled “The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy”.
Congratulations to the team of Drs. Szczesna-Cordary and kawai for having their recent article, “Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice” published in The FEBS Journal. The article explores alterations in myosin motor function and kinetics of elementary steps of a myosin cross-bridge cycle as a result of a mutation in […]
Congratulations to Vicky on the acceptance of her thesis paper in Cardiovascular Research. Well done Vicky!
We are delighted to share the news that Dr. Chen-Ching (Vicky) Yuan’s thesis paper titled “Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice” has been accepted for publication in Cardiovascular Research (MS # CVR-2016-1157R2). We are proud to have Vicky […]
Please join us in congratulating Chen-Ching (Vicky) Yuan, with the Molecular and Cellular Pharmacology (MCP) Graduate Program, who will be giving her thesis defense seminar Monday, February 27, 2017 at 12:00 P.M. in RMSB 6018. Her thesis is titled, “Structural and Functional Studies of Mouse Models of Cardiomyopathy Caused by Myosin Light Chain Mutations“. Serving […]