Danuta Szczesna-Cordary, PhD Email: email@example.com Myosin Light Chain Mutant Induced Cardiomyopathies The major theme of my research regards myosin and troponin-mediated cellular events that result in sarcomere shortening and muscle contraction studied at the molecular, myofilament and organ levels. Our recent research interests concentrate on the molecular and genetic causes of cardiomyopathy with a special […]
Hance is an undergraduate at the University of Miami, where he majors in biochemistry and aspire to enter the MD/PhD program following undergraduate studies. Hance has previously worked in the army where he most recently served as Staff Sergeant/Medical Sergeant. We hope you will enjoy your time in the DSC lab and hope you will […]
The DSC is pleased to share their newest accepted paper in FASEB which will be available in a near future untitled: “Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain”. Congrats to all lab members and collaborators for their help and contribution on this paper! […]
Our graduate student Yoel Sitbon passed his PhD proposal on September 27th! His research focuses on mutations on ELC leading to HCM and RCM and aims at further understanding the role of the N-Terminus of ELC in regulating cardiac muscle contraction in health and disease. Congrats ! Next steps for him include: elaborating on the […]
2018 Myofilament Meeting: Elastic Domains in Proteins of the Sarcomere: Stressors, Regulators or Rulers?
Dr. Szczesna-Cordary and her two graduate students Yoel Sitbon and Sunil Yadav flew to Madison where they presented their research via poster presentations & oral presentations! Very interesting and nourishing intellectual trip!
Dear Mr. Yadav, As you may know the AHA frequently partners with other funding sources such as private foundations, individual donors, and corporations to share support for projects of excellent scientific merit. I am writing to let you know that your AHA award was selected to be funded with a gift from Pamela Knous. Funds […]
In their latest paper published in The Proceedings of the National Academy of Sciences USA, the Szczesna-Cordary Lab reveals the molecular mechanisms associated with MYL2- mutant dilated cardiomyopathy: http://www.pnas.org/content/early/2018/02/15/1716925115 Yuan et al. 2018 DCM + Suppl
Poster sessions at the Moscone West Convention Center!
Our lab would like to thank our postdoc Cindy for her hard work and dedication in the DSC lab! We enjoyed having you in the lab and hope you will like your new position in Dr, Slingerland laboratory!
Our graduate student Yoel Sitbon successfully passed his Qualifying Exam on 01/25/2018 untitled: “Effect of Mutations in Myosin Essential Light Chains (ELC) on the Development of Pathological vs. Physiological Cardiac Hypertrophy”. More specifically, his project will be based on the two following aims: Specific aim 1: Morphological and contractile phenotypes and myosin motor function in heart […]
Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and will additionally look […]