Yoel Sitbon, Graduate Student

Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and  will additionally look into mitochondrial bioenergetics, a process that is tightly regulated to meet varying metabolic demands resulting from changes in cardiac load.