Danuta Szczesna-Cordary, PhD Email: firstname.lastname@example.org Myosin Light Chain Mutant Induced Cardiomyopathies The major theme of my research regards myosin and troponin-mediated cellular events that result in sarcomere shortening and muscle contraction studied at the molecular, myofilament and organ levels. Our recent research interests concentrate on the molecular and genetic causes of cardiomyopathy with a special […]
Katarzyna Kazmierczak, PhD Email: email@example.com Development of physiological versus pathological cardiac hypertrophy in animal models of cardiomyopathy expressing mutations in MYL2 and MYL3.
Jingsheng Liang, MD Email: firstname.lastname@example.org Studies of the effect of genetic mutations in MYL2 and MYL3 on the skinned fiber mechanics (force-pCa, maximal tension, passive tension).
Zhiqun Zhou, PhD Email: email@example.com Molecular mechanisms underlying malignant MYL2 mutations leading to cardiac and slow skeletal muscle myopathies. Supported by AHA 15POST25080302 (07/01/2015-06/30/2017) Cardioskeletal myopathy with onset and death in infancy, morphological features of muscle type I hypotrophy with myofibrillar disorganization and hypertrophic/dilated cardiomyopathy were previously reported in three Dutch families. Recently, Weterman et al. […]
Chen-Ching Yuan Email: firstname.lastname@example.org Structural and functional studies on animal models of hypertrophic, dilated and restrictive cardiomyopathy caused by myosin light chains mutations. Supported by AHA 15PRE23020006 Cardiomyopathy is a disease of the myocardium that could be either acquired or inherited (genetic). This study is focused on three types of inherited cardiomyopathy: hypertrophic (HCM), dilated (DCM) […]
Sunil Yadav, graduate student. Email: email@example.com The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy.
Former Graduate Student. Currently at Columbia University, New York.
Former Postdoctoral Associate. Currently at OPKO Health. Inc. Miami
Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and will additionally look […]