Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will also be studying how mutations in ELC regulate the Super-Relaxed State of myosin and will additionally look […]
We are proud to announce that Dr. Chen-Ching (Vicky) Yuan is pursuing her Post-Doctoral Fellowship at the University of Washington at Seattle in the laboratory of Dr. Michael Regnier. His laboratory studies the molecular mechanisms of cardiac and skeletal muscle disease and uses this information to develop novel gene therapies and proteins, cells and tissue engineering […]
The DSC family is excited to welcome Yoel Sitbon as its latest addition to our MCP graduate students. Yoel’s research will focus on Essential Light Chain (ELC) mutations that lead to cardiomyopathy via changes in ELC structure, and the ability of myosin to effectively interact with actin, ultimately leading to dysregulated cardiac muscle contraction. He will […]
Congratulations to Sunil Yadav ( Danuta Szczesna-Cordary Lab) for receiving a two-year American Heart Association (AHA) AWRP Winter 2017 Predoctoral Fellowship for the work titled “The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy”.
Congratulations to the team of Drs. Szczesna-Cordary and kawai for having their recent article, “Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice” published in The FEBS Journal. The article explores alterations in myosin motor function and kinetics of elementary steps of a myosin cross-bridge cycle as a result of a mutation in […]
We are delighted to share the news that Dr. Chen-Ching (Vicky) Yuan’s thesis paper titled “Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice” has been accepted for publication in Cardiovascular Research (MS # CVR-2016-1157R2). We are proud to have Vicky […]
Please join us in congratulating Chen-Ching (Vicky) Yuan, with the Molecular and Cellular Pharmacology (MCP) Graduate Program, who will be giving her thesis defense seminar Monday, February 27, 2017 at 12:00 P.M. in RMSB 6018. Her thesis is titled, “Structural and Functional Studies of Mouse Models of Cardiomyopathy Caused by Myosin Light Chain Mutations“. Serving […]
Congratulation to Chen-Ching (Vicky) on passing her sufficiency exam today. Vicky delivered a nice seminar to the entire department on October 25th at 1 PM and then presented her thesis work for the committee members. After some discussion, lots of questions and answers the committee accepted her experimental part of the dissertation as sufficient for the […]
Congrats to Cindy on her first first-author article in the Szczesna-Cordary Lab! The full article can be read by clicking on the link below: Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants