Infantile fiber-type I hypotrophy with simultaneously occurring severe onset of cardiomyopathy was reported in multiple Dutch and Italian families and genetically linked to the MYL2 gene encoding for the human myosin regulatory light chain RLCventr/slow concurrently expressed in cardiac ventricles and in slow-twitch skeletal muscles. To address the molecular origin of this novel RLCventr/slow-induced cardioskeletal […]
Structural studies on transgenic mouse papillary and soleus muscle fibers using small angle X-ray diffraction at BioCAT 18ID (Beamtime April 15-April 19, 2016). Click the title for pictures.
Former Postdoctoral Associate. Currently at OPKO Health. Inc. Miami
Former Graduate Student. Currently at Columbia University, New York.
Former Graduate Student. Currently at University of Washington, Seattle.
Former Postdoctoral Associate. Currently at laboratory of Dr. Slingerland, University of Miami, Miami.
Jingsheng Liang, MD Email: email@example.com Studies of the effect of genetic mutations in MYL2 and MYL3 on the skinned fiber mechanics (force-pCa, maximal tension, passive tension).
Katarzyna Kazmierczak, PhD Email: firstname.lastname@example.org Development of physiological versus pathological cardiac hypertrophy in animal models of cardiomyopathy expressing mutations in MYL2 and MYL3.
Danuta Szczesna-Cordary, PhD Email: email@example.com Myosin Light Chain Mutant Induced Cardiomyopathies The major theme of my research regards myosin and troponin-mediated cellular events that result in sarcomere shortening and muscle contraction studied at the molecular, myofilament and organ levels. Our recent research interests concentrate on the molecular and genetic causes of cardiomyopathy with a special […]
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