Research

Cardiomyopathy is a disease of the myocardium that could be either acquired or inherited (genetic). Our lab is focused on three types of inherited cardiomyopathy: hypertrophic (HCM), dilated (DCM) and restrictive (RCM) that occur due to mutations in the MYL2 and MYL3 genes encoding for the myosin regulatory (RLC) and essential (ELC) light chains, respectively. The normal myofilament structure of the heart muscle is important for its contractile function and any alterations in myofilament architecture may trigger abnormal cardiac remodeling leading to HCM, DCM and RCM.

Below are selected slides from the talk at Myofilament Conference Madison, WI on May 19-23, 2019.

Myosin Light Chains And Their Heavy Roles