We are very pleased to present our newest publications: Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain Slow-twitch skeletal muscle defects accompany cardiac dysfunction in […]
Our graduate student Yoel Sitbon passed his PhD proposal on September 27th! His research focuses on mutations on ELC leading to HCM and RCM and aims at further understanding the role of the N-Terminus of ELC in regulating cardiac muscle contraction in health and disease. Congrats ! Next steps for him include: elaborating on the […]
2018 Myofilament Meeting: Elastic Domains in Proteins of the Sarcomere: Stressors, Regulators or Rulers?
Dr. Szczesna-Cordary and her two graduate students Yoel Sitbon and Sunil Yadav flew to Madison where they presented their research via poster presentations & oral presentations! Very interesting and nourishing intellectual trip!
Dear Mr. Yadav, As you may know the AHA frequently partners with other funding sources such as private foundations, individual donors, and corporations to share support for projects of excellent scientific merit. I am writing to let you know that your AHA award was selected to be funded with a gift from Pamela Knous. Funds […]
In their latest paper published in The Proceedings of the National Academy of Sciences USA, the Szczesna-Cordary Lab reveals the molecular mechanisms associated with MYL2- mutant dilated cardiomyopathy: http://www.pnas.org/content/early/2018/02/15/1716925115 Yuan et al. 2018 DCM + Suppl
Our lab would like to thank our postdoc Cindy for her hard work and dedication in the DSC lab! We enjoyed having you in the lab and hope you will like your new position in Dr, Slingerland laboratory!
Our graduate student Yoel Sitbon successfully passed his Qualifying Exam on 01/25/2018 untitled: “Effect of Mutations in Myosin Essential Light Chains (ELC) on the Development of Pathological vs. Physiological Cardiac Hypertrophy”. More specifically, his project will be based on the two following aims: Specific aim 1: Morphological and contractile phenotypes and myosin motor function in heart […]
Jacob Rowe, first year graduate PIBS student gave his rotation symposium talk today! His project focused on two different mutations in the Essential Light Chain of myosin (A57G and D43) and how each modulate the Super Relaxed State (SRX) of myosin. Thank you for all the help and we hope you enjoyed your time in […]
Congratulation to Chen-Ching (Vicky) on passing her sufficiency exam today. Vicky delivered a nice seminar to the entire department on October 25th at 1 PM and then presented her thesis work for the committee members. After some discussion, lots of questions and answers the committee accepted her experimental part of the dissertation as sufficient for the […]