Congratulation to Chen-Ching (Vicky) on passing her sufficiency exam today. Vicky delivered a nice seminar to the entire department on October 25th at 1 PM and then presented her thesis work for the committee members. After some discussion, lots of questions and answers the committee accepted her experimental part of the dissertation as sufficient for the […]
Sunil Yadav, graduate student. Email: firstname.lastname@example.org The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy.
Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
Congrats to Cindy on her first first-author article in the Szczesna-Cordary Lab! The full article can be read by clicking on the link below: Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
Project 3. Therapeutic potential of myosin Regulatory Light Chain (RLC) phosphorylation in treatment of heart disease
Genetic cardiomyopathies are the most prevalent inherited heart diseases and no therapies are currently available to cure or delay progression from hypertrophy to heart failure, and/or to prevent sudden cardiac death. Thus, efforts must be undertaken to develop new and effective therapeutic strategies. In this research project we aim to explore the therapeutic potential of the pseudo-phosphorylated […]
This research project focuses on elucidating the mechanisms by which mutations in the ventricular myosin essential light chain (ELC) lead to different hypertrophic remodeling in the hearts of transgenic mice. We are using single molecule, phosphoproteomic and in vivo approaches to elucidate the ELC-mediated normal (in Δ43 & WT mice) versus pathological (in A57G & […]
Project 1. Cardioskeletal myopathy associated with mutations in the MYL2 gene encoding for the myosin Regulatory Light Chain (RLC) in the heart and in slow-twitch skeletal muscle
Infantile fiber-type I hypotrophy with simultaneously occurring severe onset of cardiomyopathy was reported in multiple Dutch and Italian families and genetically linked to the MYL2 gene encoding for the human myosin regulatory light chain RLCventr/slow concurrently expressed in cardiac ventricles and in slow-twitch skeletal muscles. To address the molecular origin of this novel RLCventr/slow-induced cardioskeletal […]
Structural studies on transgenic mouse papillary and soleus muscle fibers using small angle X-ray diffraction at BioCAT 18ID (Beamtime April 15-April 19, 2016). Click the title for pictures.
Former Postdoctoral Associate. Currently at OPKO Health. Inc. Miami
Former Graduate Student. Currently at Columbia University, New York.
Chen-Ching Yuan Email: email@example.com Structural and functional studies on animal models of hypertrophic, dilated and restrictive cardiomyopathy caused by myosin light chains mutations. Supported by AHA 15PRE23020006 Cardiomyopathy is a disease of the myocardium that could be either acquired or inherited (genetic). This study is focused on three types of inherited cardiomyopathy: hypertrophic (HCM), dilated (DCM) […]