Congratulations to Sunil Yadav ( Danuta Szczesna-Cordary Lab) for receiving a two-year American Heart Association (AHA) AWRP Winter 2017 Predoctoral Fellowship for the work titled “The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy”.
Congratulations to the team of Drs. Szczesna-Cordary and kawai for having their recent article, “Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice” published in The FEBS Journal. The article explores alterations in myosin motor function and kinetics of elementary steps of a myosin cross-bridge cycle as a result of a mutation in […]
Congratulations to Vicky on the acceptance of her thesis paper in Cardiovascular Research. Well done Vicky!
We are delighted to share the news that Dr. Chen-Ching (Vicky) Yuan’s thesis paper titled “Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice” has been accepted for publication in Cardiovascular Research (MS # CVR-2016-1157R2). We are proud to have Vicky […]
Please join us in congratulating Chen-Ching (Vicky) Yuan, with the Molecular and Cellular Pharmacology (MCP) Graduate Program, who will be giving her thesis defense seminar Monday, February 27, 2017 at 12:00 P.M. in RMSB 6018. Her thesis is titled, “Structural and Functional Studies of Mouse Models of Cardiomyopathy Caused by Myosin Light Chain Mutations“. Serving […]
Congratulation to Chen-Ching (Vicky) on passing her sufficiency exam today. Vicky delivered a nice seminar to the entire department on October 25th at 1 PM and then presented her thesis work for the committee members. After some discussion, lots of questions and answers the committee accepted her experimental part of the dissertation as sufficient for the […]
Sunil Yadav, graduate student. Email: email@example.com The effect of pseudo-phosphorylation of myosin RLC on improvement of cardiac function in hypertrophic cardiomyopathy.
Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
Congrats to Cindy on her first first-author article in the Szczesna-Cordary Lab! The full article can be read by clicking on the link below: Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
Project 3. Therapeutic potential of myosin Regulatory Light Chain (RLC) phosphorylation in treatment of heart disease
Genetic cardiomyopathies are the most prevalent inherited heart diseases and no therapies are currently available to cure or delay progression from hypertrophy to heart failure, and/or to prevent sudden cardiac death. Thus, efforts must be undertaken to develop new and effective therapeutic strategies. In this research project we aim to explore the therapeutic potential of the pseudo-phosphorylated […]
This research project focuses on elucidating the mechanisms by which mutations in the ventricular myosin essential light chain (ELC) lead to different hypertrophic remodeling in the hearts of transgenic mice. We are using single molecule, phosphoproteomic and in vivo approaches to elucidate the ELC-mediated normal (in Δ43 & WT mice) versus pathological (in A57G & […]